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Predictor(TM) hERG Fluorescence Polarization Assay Kit performed on the PHERAstar/PHERAstar Plus
The potential for cardiotoxic side-effects continues to challenge the development of small molecule based therapies. These intolerable side-effects are often precipitated by drug-induced long QT syndrome (LQT), which is often linked to blocking the human ether-a-go-go related gene (hERG) potassium channel. Although patch-clamp electrophysiology remains the gold standard for determining the interaction of compounds with the function of the hERG channel, radioligand displacement assays have proven to be a cost-effective initial alternative assay for hERG channel liability at early stages of compound development....
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"Green Chemstry" in the Laboratory
Using mills as efficient and ecologically friendly synthesis reactors
The term "green chemistry" is commonly used to describe chemical procedures which meet specific requirements with regards to the conservation of resources and protection of the environment. The objective is to avoid undesired by-products by selecting adequate reaction procedures and media. A typical example is the production of bio fuel which has become an ecologically friendly alternative for many drivers....
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Nature's Ingenuity Shows the Way
FusionOpticsTM - The New Dimension of Stereomicroscopy
Up to 80 percent of our experience of our visual environment takes place via our visual perception. Without spatial vision, we would hardly be able to stay oriented. In recent decades, the neurosciences have gained many insights into the complex processes by which our brain's visual cortex and cerebral cortex do the fascinating job of processing the signals originating from the eyes into an image. A study carried out jointly by Leica Microsystems and the Institute of Neuroinformatics at the University of Zurich and Swiss Federal Institute of Technology showed how flexible and powerfull our brain joins visual signals to create an optimal spatial image. The results provided the basis for an innovation in stereomicroscopy which, in terms of resolution and focus depth, has broken through limits that were previously impossible to overcome....
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Sensible and self-monitoring
Online process for soft water control
For the generation of soft water are mostly used ion exchanging devices with generation of sodium chloride since the beginning of the Sixties. The generated soft water quality and soft water quantity are depending thereby on the static and dynamic characteristics of the softening plant in operation....
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Efficient Transfection of Primary Human Skeletal Myoblasts Using FuGENE® HD Transfection Reagent
Transfection of cells is one of the main techniques used to influence gene expression. Most primary cells and human skeletal myoblasts (SkMC) in particular are very difficult to transfect, whereas for cell lines such as C2C12, many suitable transfection reagents and protocols are available. Few publications report successful transfection of human primary myoblasts using non-viral systems [1,2,3]. These methods include cationic lipids such as phosphonolipids, electroporation, and a combination of liposome and adenoviral associated proteins. But transfection efficiency is low and often is a compromise between toxicity of the reagents and transfection efficiency....
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